| Razne fiziološki aktivne supstancije koje su ili autakoidi ili ncurotransmitori. na svoj način utiču na motilitet i sekreciju želuca i crijeva. Kod peradi se o ulozi ovih supstancija ti normalnom održavanju funkcije gastrointcstinalnog trakta skoro ništa ne zna. Može se reći da je jasan jedino holinergični mehanizam, jer se zna da su zastupljedni holinergični reeeptori, ali se ne zna koja je vrsta histaminskih reeeptora zastupljena (Hi, H^\ Hi). Prema tome ne znaju se ni mogući efekti ekscitatora (agonista) niti blokatora (antagonista), što autamatski reducira i broj potencijalnih lijekova. Od svih njih najinteresantniji su histaminergični reeeptori. jer je uticaj histamina, naročito u patološkim stanjima jako važan. Zbog toga bi utvrđivanje tipova reeeptora za hisiamin omogućilo primjenu njihovih ekscitatora. odnosno blokatora, a to bi bez sumnje obogatilo l'armakoterapiju poremećene funkcije crijeva peradi. |
Different physiologically active substances, which are either autacoids or neurotransmitters. influence motility and secretion of the stomach and of the intestines. There is very little information out there about the role
of these substances in maintaining the function of gastrointestinal system in poultry. One thing that is clear, however, is the cholincrgic mechanism because it is known that there are cholinergie receptors in intestines. At the same time, however, it remains unclear which of those receptors are present (H1, H2 and H3). Moreover, the possible effects of excitators (agonists) or blockers (antagonist) remain unclear and this automatical reduces the number of potential drugs. Out of all of them, the most interesting are histamineruic receptors, because the influence of hislamine. especially during the pathological states, is very important. This is the reason that identification of receptor types for hislaminc would enable the application of their excilalors or blocke is and this could consequently lead to better therapy of intestines mall unction with poultry.
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